Engineering scalable biological systems

Engineering scalable biological systems.

Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, processing logic and performing output functions. In the last decade, significant progress has been made ...

Synthetic Biology: Engineering Biological Systems

On June 26, 2000, President Bill Clinton and Prime Minister Tony Blair, along with Francis Collins, director of the Human Genome Project at the NIH, and Craig Venter, president of Celera Genomics, announced the arrival of the genomic era with the sequencing of the first draft sequence of the human genome. With this wealth of information, scientists and policy-makers alike were eager to welcome ...

Why complex systems engineering needs biological development

Here we shall discuss the need of Complex Systems Engineering to adopt principles from natural development of complex biological organisms—besides principles of natural evolution—to acomplish the type of performance that biology achieves regularly. We shall situate Complex Systems Engineering and discuss an example of how it could be employed. © 2007 Wiley Periodicals, Inc. Complexity 13:12–21,...

Cooperativity in biological systems

Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...

Designing Scalable Biological Interfaces